One of the most significant events in Black history related to the U.S. Presidency is the election of Barack Obama as the first African American President of the United States. Obama's historic election in 2008 marked a major milestone in American history and was a significant step forward in the struggle for racial equality. During his two terms in office, President Obama worked to address issues of racial and social injustice, expanding healthcare access through the Affordable Care Act, championing LGBTQ rights, and implementing economic policies to address the Great Recession.

Another important figure in Black history and the U.S. Presidency is Frederick Douglass, who was the first African American to be nominated for Vice President of the United States in 1872 as the running mate of Victoria Woodhull on the Equal Rights Party ticket.

Additionally, figures such as Shirley Chisholm, who became the first African American woman elected to Congress in 1968 and later ran for the Democratic nomination for President in 1972, and Jesse Jackson, who ran for the Democratic nomination for President in 1984 and 1988, have also made significant contributions to Black history in relation to the U.S. Presidency.